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The evolution of cancer or the sequelae of its treatment cause pain. Symptoms and location will vary depending on the type of tumor. The availability of extended-release opioid analgesics facilitates pain control in these patients, although sometimes the intensity of the pain or the existence of too many pharmacological side effects will render the use of other approaches advisable (neurolytic blockades, radiofrequency thermocoagulation, implantable continuous epidural or intrathecal administration systems). The pain clinic can offer all these alternatives to patients requiring them.